| Primary Identifier | MGI:108061 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 22410 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cytokine activity and frizzled binding activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of cell differentiation; and regulation of DNA-templated transcription. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including genitourinary system; integumental system; jaw; nervous system; and surface ectoderm. Human ortholog(s) of this gene implicated in obesity; split hand-foot malformation 6; and tooth agenesis. Orthologous to human WNT10B (Wnt family member 10B). PHENOTYPE: Homozygous mutant mice fed a low- or high-fat diet exhibit accelerated myogenic differentiation of myoblasts and those fed a high-fat diet exhibit excessive lipid accumulation in actively regenerating muscle. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
