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Protein Coding Gene : Tmprss12 transmembrane (C-terminal) protease, serine 12
Primary Identifier  MGI:1922252 Organism  mouse, laboratory
Chromosome  15 NCBI Gene Number  75002
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable serine-type endopeptidase activity. Involved in acrosome assembly and positive regulation of sperm capacitation. Acts upstream of or within binding activity of sperm to zona pellucida and protein processing. Located in acrosomal vesicle. Orthologous to human TMPRSS12 (transmembrane serine protease 12).
PHENOTYPE: Homozygous null mutations of this gene result in male infertility associated with oligozoospermia, asthenozoospermia, and impaired fertilization. [provided by MGI curators]
  • synonyms:
  • transmembrane (C-terminal) protease, serine 12,
  • 4930478A21Rik,
  • Tmprss12,
  • RIKEN cDNA 4930478A21 gene
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3 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

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Canonical gene --> Transcripts in specific strains.

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