| Primary Identifier | MGI:1915864 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 68614 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables molecular adaptor activity. Involved in mitochondrion organization and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including ATP biosynthetic process; non-canonical NF-kappaB signal transduction; and toll-like receptor 4 signaling pathway. Located in mitochondrial inner membrane. Is active in nucleus. Is expressed in brain; cranial ganglion; dorsal root ganglion; and retina. Orthologous to human LETMD1 (LETM1 domain containing 1). PHENOTYPE: Mice homozygous for a null allele exhibit impaired adaptive thermogenesis, whitened brown adipose tissue morphology, and increased susceptibility to diet-induced obesity and metabolic dysfunction. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
