Primary Identifier | MGI:1928745 | Organism | mouse, laboratory |
Chromosome | 15 | NCBI Gene Number | 59033 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables sodium,bicarbonate:chloride antiporter activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within positive regulation of synaptic vesicle exocytosis and regulation of intracellular pH. Located in several cellular components, including basolateral plasma membrane; neuronal cell body membrane; and presynapse. Is active in glutamatergic synapse and presynaptic membrane. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and sensory organ. Orthologous to human SLC4A8 (solute carrier family 4 member 8). PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal sodium and chloride ion excretion. [provided by MGI curators] |