| Primary Identifier | MGI:1352454 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 15370 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and lipopolysaccharide binding activity. Involved in several processes, including cellular response to corticotropin-releasing hormone stimulus; detection of lipopolysaccharide; and non-canonical inflammasome complex assembly. Acts upstream of or within several processes, including negative regulation of cysteine-type endopeptidase activity; positive regulation of transcription by RNA polymerase II; and skeletal muscle cell differentiation. Located in chromatin; cytosol; and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; clavicle; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human NR4A1 (nuclear receptor subfamily 4 group A member 1). PHENOTYPE: Mice homozygous for a targeted null mutation are viable, fertile, and display a normal HPA axis function, as well as normal thymic and peripheral T cell deletion. Homozygous KO decreases apoptosis and increases proliferation of B cell stimulated by a single antigen. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
