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Protein Coding Gene : Krt75 keratin 75
Primary Identifier  MGI:1923500 Organism  mouse, laboratory
Chromosome  15 NCBI Gene Number  109052
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to be a structural constituent of skin epidermis. Acts upstream of or within hematopoietic progenitor cell differentiation. Is active in cornified envelope. Is expressed in incisor; larynx; skin; urethra; and ventral grey horn. Orthologous to human KRT75 (keratin 75).
PHENOTYPE: Mice homozygous for a knock-in mutation that results in the deletion of the highly conserved asparagine residue (N159) in the helix initiation peptide of this gene develop hair shaft and nail abnormalities resembling pachyonychia congenita. [provided by MGI curators]
  • synonyms:
  • AA589387,
  • expressed sequence AA589387,
  • K6hf,
  • keratinocyte associated protein 1,
  • RIKEN cDNA 4732468K03 gene,
  • MGI:2145919,
  • Krt2-6hf,
  • Krt75,
  • 4732468K03Rik,
  • keratin 75,
  • Krtcap1
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Features --> Cross References

Genome

Sequence Feature Displayer

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4 Involved In Mutations

Trail: ProteinCodingGene

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

3 Pathways

Trail: ProteinCodingGene

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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