| Primary Identifier | MGI:96701 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 16682 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to be a structural constituent of skin epidermis. Involved in epithelial cell differentiation and negative regulation of epithelial cell proliferation. Predicted to be located in cell surface and intermediate filament cytoskeleton. Predicted to be active in keratin filament. Is expressed in several structures, including alimentary system; lower urinary tract; respiratory system; sensory organ; and skin. Used to study white sponge nevus. Human ortholog(s) of this gene implicated in white sponge nevus 1. Orthologous to human KRT4 (keratin 4). PHENOTYPE: Mice homozygous for disruptions in this gene display hyperplasia throughout the epithelium of the esophagus and tongue. Mice homozygous or heterozygous for a dominant mutation display oral leukoplakia and homozygotes display postnatal growth retardation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
