| Primary Identifier | MGI:1918339 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 71089 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including GTP binding activity; GTPase activity; and protein homodimerization activity. Predicted to be involved in cytoskeleton-dependent cytokinesis and protein localization. Predicted to be located in several cellular components, including midbody; perinuclear region of cytoplasm; and sperm annulus. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Is expressed in testis. Human ortholog(s) of this gene implicated in spermatogenic failure 10. Orthologous to human SEPTIN12 (septin 12). PHENOTYPE: Male chimeras heterozygous for a null allele are sterile due to severe spermatogenic defects. Males homozygous for a different null allele are sterile and show oligospermia, asthenospermia, abnormal sperm morphology, and impaired egg activation and fertilization after intracytoplasmic sperm injection, whereas heterozygous males are fertile. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
