Primary Identifier | MGI:1916303 | Organism | mouse, laboratory |
Chromosome | 16 | NCBI Gene Number | 69053 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of signal transduction by p53 class mediator and regulation of cellular response to stress. Predicted to be located in cytoplasm and nucleus. Is expressed in retina; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human HAPSTR1 (HUWE1 associated protein modifying stress responses). PHENOTYPE: Mice with loss of expression display lethality throughout fetal growth and development with reduced fetal size and impaired proliferation of MEFs. [provided by MGI curators] |