Primary Identifier | MGI:2444505 | Organism | mouse, laboratory |
Chromosome | 16 | NCBI Gene Number | 223989 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable CCR4-NOT complex binding activity. Involved in female meiotic nuclear division; oogenesis; and regulation of gene expression. Acts upstream of or within double-strand break repair. Predicted to be located in Golgi apparatus and peroxisome. Predicted to be active in cytoplasm. Is expressed in central nervous system; early conceptus; oocyte; and sensory organ. Orthologous to human MARF1 (meiosis regulator and mRNA stability factor 1). PHENOTYPE: Mice homozygous for an ENU-induced mutation exhibit female infertility with abnormalities in oogenic processes including meiotic progression, genomic integrity and acquisition of developmental competence. [provided by MGI curators] |