| Primary Identifier | MGI:102676 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 17250 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including ABC-type transporter activity; glutathione transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including cellular response to amyloid-beta; cobalamin transport; and leukotriene transport. Located in plasma membrane. Is active in basal plasma membrane. Is expressed in several structures, including embryo mesenchyme; genitourinary system; hemolymphoid system; nervous system; and nose. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 77 and chronic obstructive pulmonary disease. Orthologous to human ABCC1 (ATP binding cassette subfamily C member 1 (ABCC1 blood group)). PHENOTYPE: Mice homozygous for targeted mutations that inactivate the gene have a reduced response to inflammatory stimulus, increased levels of glutathione due to impaired metabolism, and are hypersensitive to the anticancer drug etoposide. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
