Primary Identifier | MGI:2676849 | Organism | mouse, laboratory |
Chromosome | 16 | NCBI Gene Number | 387180 |
Mgi Type | miRNA gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within cellular response to leukemia inhibitory factor and regulation of SMAD protein signal transduction. Is expressed in several structures, including eye; gonad; hemolymphoid system gland; liver; and lung. Orthologous to human MIR185 (microRNA 185). PHENOTYPE: Mice homozygous for a null allele do not exhibit spontaneous phenotypes. Ovariectomized females show decreased osteoporosis development and primary osteoblasts and mesenchymal stem cells show enhanced osteogenesis in culture. [provided by MGI curators] |