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Protein Coding Gene : Senp2 SUMO/sentrin specific peptidase 2
Primary Identifier  MGI:1923076 Organism  mouse, laboratory
Chromosome  16 NCBI Gene Number  75826
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables deSUMOylase activity. Involved in fat cell differentiation and protein desumoylation. Acts upstream of or within several processes, including embryonic placenta development; positive regulation of transcription by RNA polymerase II; and regulation of cell cycle process. Located in nuclear body. Colocalizes with PML body. Is expressed in several structures, including blastocyst; central nervous system; early embryo; extraembryonic component; and retina. Orthologous to human SENP2 (SUMO specific peptidase 2).
PHENOTYPE: Homozygous null mice are embryonic lethal due to placental defects resulting from abnormal trophoblast maturation. [provided by MGI curators]
  • synonyms:
  • MGI:2146470,
  • mKIAA1331,
  • 4930538C18Rik,
  • RIKEN cDNA 4930538C18 gene,
  • expressed sequence AW554757,
  • Senp2,
  • RIKEN cDNA 2310007L05 gene,
  • SUMO/sentrin specific peptidase 2,
  • AW554757,
  • expressed sequence AI646780,
  • 2310007L05Rik,
  • MGI:2146665,
  • AI646780,
  • MGI:1916738
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