Primary Identifier | MGI:1332234 | Organism | mouse, laboratory |
Chromosome | 16 | NCBI Gene Number | 22661 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within gamete generation and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and hemolymphoid system. Orthologous to human ZNF148 (zinc finger protein 148). PHENOTYPE: Disruption of one allele results in haploinsufficient male infertility in which chimeric males display a loss of germ cells. [provided by MGI curators] |