| Primary Identifier | MGI:104568 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 15163 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables SH3 domain binding activity. Involved in several processes, including erythrocyte differentiation; positive regulation of myeloid leukocyte differentiation; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in thymus primordium. Orthologous to human HCLS1 (hematopoietic cell-specific Lyn substrate 1). PHENOTYPE: Mice homozygous for disruptions in this gene show impaired antibody production to T-independent antigen and impaired proliferative responses of splenic B and T cells after cross-linking of antigen receptors. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
