| Primary Identifier | MGI:94925 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 13490 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in behavioral response to cocaine and regulation of neurotransmitter uptake. Acts upstream of or within several processes, including adenylate cyclase-activating dopamine receptor signaling pathway; regulation of blood pressure; and regulation of dopamine receptor signaling pathway. Located in plasma membrane. Is active in dopaminergic synapse. Is expressed in several structures, including brain; exocrine gland; genitourinary system; gut; and sensory organ. Used to study restless legs syndrome. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (dopamine receptor D3). PHENOTYPE: Homozygous mutants show exploratory hyperactivity and increased locomotion and rearing behavior, with heterozygous mice displaying similar, but less pronounced, behaviors. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
