| Primary Identifier | MGI:95814 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 14805 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables L-glutamate transmembrane transporter activity and kainate selective glutamate receptor activity. Acts upstream of or within several processes, including chemical synaptic transmission; modulation of chemical synaptic transmission; and positive regulation of gamma-aminobutyric acid secretion. Located in dendrite; postsynaptic density; and presynaptic membrane. Part of kainate selective glutamate receptor complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in childhood absence epilepsy. Orthologous to human GRIK1 (glutamate ionotropic receptor kainate type subunit 1). PHENOTYPE: Mice homozygous for disruptions in this gene display subtile abnormalities in the electrophysiology of neurons in the brain. Response to chemical pain stimuli is also reduced. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
