Primary Identifier | MGI:98307 | Organism | mouse, laboratory |
Chromosome | 16 | NCBI Gene Number | 20465 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA binding activity and protein heterodimerization activity. Acts upstream of or within embryonic pattern specification; lung development; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; future brain; genitourinary system; limb; and skeleton. Orthologous to human SIM2 (SIM bHLH transcription factor 2). PHENOTYPE: Homozygous mutation of this gene results in postnatal lethality, cleft palate, malformed pterygoid processes, and aerophagia. [provided by MGI curators] |