| Primary Identifier | MGI:1333817 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 20519 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables monoamine transmembrane transporter activity; neurotransmitter transmembrane transporter activity; and quaternary ammonium group transmembrane transporter activity. Involved in histamine transport and monoamine transport. Acts upstream of or within several processes, including histamine uptake; quaternary ammonium group transport; and regulation of appetite. Located in several cellular components, including apical plasma membrane; mitochondrial membrane; and neuronal cell body. Is expressed in several structures, including brain; dermis; extraembryonic component; genitourinary system; and thymus primordium. Orthologous to human SLC22A3 (solute carrier family 22 member 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to paraquat-induced dopamine neuron neurotoxicity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
