| Primary Identifier | MGI:1345143 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 23984 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables 3',5'-cyclic-nucleotide phosphodiesterase activity. Acts upstream of or within regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of cAMP/PKA signal transduction. Is active in glutamatergic synapse. Is expressed in alimentary system; cardiovascular system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in striatal degeneration 2. Orthologous to human PDE10A (phosphodiesterase 10A). PHENOTYPE: Homozygous mutation of this gene results in decreased exploratory behavior, hypoactivity, and a delay in the acquisition of conditioned avoidance behavior. A hypomorphic allele results in increased social behavior. Mice homozygous for a knock-out allele exhibit resistance to diet-induced obesity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
