| Primary Identifier | MGI:2442952 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 268932 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable identical protein binding activity and protein domain specific binding activity. Involved in regulation of postsynaptic density assembly. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including adrenal gland; bladder; eye; intestine; and nervous system. Orthologous to human CASKIN1 (CASK interacting protein 1). PHENOTYPE: Homozygous mice for a null allele exhibit abnormal gait, enhanced nociception, abnormal anxiety-like behavior, strong freezing responses with or without cue tone in contextual and cued-fear conditioning tasks and low memory retention. Double homozygous KO with Caskin2 affects synapse efficacy in the brain and leads to spatial learning and novel object recognition deficits. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
