| Primary Identifier | MGI:1353598 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 30957 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables MAP-kinase scaffold activity; kinesin binding activity; and protein kinase binding activity. Involved in several processes, including anterograde axonal protein transport; positive regulation of neuron migration; and regulation of MAPK cascade. Acts upstream of or within several processes, including JNK cascade; lung development; and nervous system development. Located in several cellular components, including Golgi membrane; axolemma; and smooth endoplasmic reticulum. Is expressed in several structures, including brain; genitourinary system; pancreas; retina; and spleen. Orthologous to human MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3). PHENOTYPE: Homozygous inactivation of this gene results in impaired lung morphogenesis, causes absence of the telencephalic commissure with multiple defects in brain development and axon guidance, may affect synaptic transmission, and invariably leads to neonatal death due to respiratory failure. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
