Primary Identifier | MGI:2681414 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 328780 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables heparin binding activity and serine-type peptidase activity. Predicted to be involved in proteolysis. Located in extracellular matrix and extracellular space. Is expressed in several structures, including dermis; immune system; lung; skeletal muscle; and testis. PHENOTYPE: Mice homozygous for a knock-out allele show ameliorated IgE-mediated chronic allergic inflammation in the skin, with reduced microvascular permeability and leukocyte infiltration in the skin lesion. [provided by MGI curators] |