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Protein Coding Gene : Dusp1 dual specificity phosphatase 1

Primary Identifier  MGI:105120 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  19252
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables mitogen-activated protein kinase binding activity and phosphoprotein phosphatase activity. Involved in negative regulation of MAPK cascade and negative regulation of cell population proliferation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; heart; limb; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human DUSP1 (dual specificity phosphatase 1).
PHENOTYPE: Homozygous mutant mice were viable, fertile, and showed no apparent morphological defects. [provided by MGI curators]
  • synonyms:
  • U19515,
  • Ptpn16,
  • MGD-MRK-32161,
  • mkp-1,
  • 3CH134,
  • expressed sequence U19515,
  • Dusp1,
  • protein tyrosine phosphatase, non-receptor type 16,
  • erp,
  • MKP1,
  • MGI:2147160,
  • dual specificity phosphatase 1

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

6 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For