| Primary Identifier | MGI:1277179 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 18585 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables 3',5'-cyclic-GMP phosphodiesterase activity. Involved in cGMP catabolic process and positive regulation of cardiac muscle hypertrophy. Predicted to be located in several cellular components, including nucleoplasm; perikaryon; and sarcolemma. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human PDE9A (phosphodiesterase 9A). PHENOTYPE: Mice homozygous for a null allele exhibit suppressed pressure-overload-induced cardiac pathobiology. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
