| Primary Identifier | MGI:1921627 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 74377 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in meiosis I and spermatogenesis. Located in chromosome. Is expressed in several structures, including genitourinary system; nervous system; sensory organ; surface ectoderm; and thymus. Used to study primary ovarian insufficiency 19. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 19. Orthologous to human HSF2BP (heat shock transcription factor 2 binding protein). PHENOTYPE: Homozygous knockout affects double-stranded DNA break repair, resulting in abnormal meiosis, which in turn leads to male sterility. KO mice are born at lower than expected Mendelian ratio. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
