Primary Identifier | MGI:107711 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 17916 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within several processes, including defense response to Gram-positive bacterium; neutrophil degranulation; and positive regulation of neutrophil migration. Located in cortical actin cytoskeleton. Part of filamentous actin. Is expressed in several structures, including brain; genitourinary system; heart; hemolymphoid system gland; and liver. Orthologous to human MYO1F (myosin IF). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired neutrophil migration and adhesion. [provided by MGI curators] |