| Primary Identifier | MGI:95936 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 15018 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable several functions, including 14-3-3 protein binding activity; TAP binding activity; and signaling receptor binding activity. Acts upstream of or within cellular response to type II interferon and embryo implantation. Predicted to be located in several cellular components, including Golgi medial cisterna; bounding membrane of organelle; and endoplasmic reticulum exit site. Predicted to be part of MHC class I peptide loading complex; MHC class I protein complex; and MHC class Ib protein complex. Predicted to be active in endoplasmic reticulum; external side of plasma membrane; and extracellular region. Is expressed in several structures, including 2-cell stage conceptus; 4-8 cell stage conceptus; brain; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in several diseases, including arthritis (multiple); asthma (multiple); eye disease (multiple); inner ear disease (multiple); and vasculitis (multiple). Orthologous to several human genes including HLA-B (major histocompatibility complex, class I, B); HLA-C (major histocompatibility complex, class I, C); and HLA-F (major histocompatibility complex, class I, F). PHENOTYPE: This locus controls a widely distributed lymphocyte antigen recognized by monoclonal antibody, serology or CTL assay. Using all assays, antigen is present (allele a) in C57BL/6, DBA/1, DBA/2 and SWR and absent (allele b) in AKR, C3H and BALB/c. Other strain allele typings were assay-dependent. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
