Primary Identifier | MGI:98215 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 20182 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin DNA binding activity and transcription cis-regulatory region binding activity. Involved in cellular response to retinoic acid. Acts upstream of or within several processes, including cardiac muscle tissue development; maternal placenta development; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; sensory organ; and urinary system. Orthologous to human RXRB (retinoid X receptor beta). PHENOTYPE: Mutant mice homozygous for a null mutation exhibit partial embryonic and perinatal lethality, and surviving adult males are sterile due to defects in spermatogenesis. [provided by MGI curators] |