| Primary Identifier | MGI:99495 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 14312 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables lysine-acetylated histone binding activity. Involved in several processes, including chromatin looping; positive regulation of T-helper 17 cell lineage commitment; and protein localization to chromatin. Acts upstream of or within neural tube closure. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; jaw; retina; and urinary system. Human ortholog(s) of this gene implicated in B-cell lymphoma; B-lymphoblastic leukemia/lymphoma; juvenile myoclonic epilepsy; and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2). PHENOTYPE: Mice homozygous for a null mutation display embryonic lethality during organogenesis with decreased embryo size, decreased cell proliferation, a delay in the cell cycle, and increased cell death. Heterozygous mice also display decreased cell proliferation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
