| Primary Identifier | MGI:99517 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 15511 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein folding chaperone. Involved in protein folding. Acts upstream of or within several processes, including binding activity of sperm to zona pellucida; negative regulation of cysteine-type endopeptidase activity; and response to heat. Located in cell body and mitochondrion. Part of zona pellucida receptor complex. Is expressed in several structures, including early conceptus; heart; humerus; and lung. Human ortholog(s) of this gene implicated in several diseases, including brain ischemia; obesity; toxic shock syndrome; type 2 diabetes mellitus; and urinary tract infection. Orthologous to human HSPA1B (heat shock protein family A (Hsp70) member 1B). PHENOTYPE: Homozygous mutation of this gene results in increased susceptibility to focal cerebral ischemic injury. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
