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Protein Coding Gene : Mpig6b megakaryocyte and platelet inhibitory receptor G6b
Primary Identifier  MGI:2146995 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  106722
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Acts upstream of or within blood coagulation; integrin-mediated signaling pathway; and myeloid cell differentiation. Predicted to be located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human MPIG6B (megakaryocyte and platelet inhibitory receptor G6b).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit macrothrombocytopenic, increased platelet turnover, enlarged spleen, extramedullary hematopoiesis, myelofibrosis, increased bleeding time, and impaired stimulated platelet adhesion, aggregation and ATP sectretion. [provided by MGI curators]
  • synonyms:
  • immunoreceptor tyrosine-based inhibitory motif (ITIM) containing platelet receptor,
  • expressed sequence AU023871,
  • G6b,
  • AU023871,
  • megakaryocyte and platelet inhibitory receptor G6b,
  • MGI:5908185,
  • Mpig6b
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Trail: ProteinCodingGene

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