Primary Identifier | MGI:88548 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 13001 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; identical protein binding activity; and ribonucleoprotein complex binding activity. Predicted to be involved in several processes, including adiponectin-activated signaling pathway; positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and symbiont-mediated disruption of host cell PML body. Predicted to be located in cell projection; chromatin; and nuclear matrix. Predicted to be part of PcG protein complex and protein kinase CK2 complex. Predicted to be active in PML body and cytoplasm. Predicted to colocalize with plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; nasal epithelium; and skin. Orthologous to human CSNK2B (casein kinase 2 beta). PHENOTYPE: Mice homozygous for a targeted mutation exhibit embryonic lethality post-implantation, growth retardation and arrest, a failure to form an inner cell mass and smaller size. [provided by MGI curators] |