| Primary Identifier | MGI:99204 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 22715 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin binding activity and double-stranded methylated DNA binding activity. Involved in autosome genomic imprinting; epigenetic programing of female pronucleus; and negative regulation of gene expression via chromosomal CpG island methylation. Acts upstream of or within epigenetic programming in the zygotic pronuclei; genomic imprinting; and negative regulation of transcription by RNA polymerase II. Located in heterochromatin and nucleus. Is expressed in several structures, including early conceptus; genitourinary system; liver; nervous system; and retina. Orthologous to human ZFP57 (ZFP57 zinc finger protein). PHENOTYPE: Mice homozygous for a knock-out allele exhibit some postnatal lethality with abnormal imprinting and fetal lethality observed in the homozygous offspring of homozygous females. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
