| Primary Identifier | MGI:1860139 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 54393 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential and G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential. Acts upstream of or within gamma-aminobutyric acid signaling pathway. Located in cytoplasm; postsynaptic membrane; and presynaptic membrane. Part of G protein-coupled receptor dimeric complex. Is active in GABA-ergic synapse and Schaffer collateral - CA1 synapse. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in alcohol dependence; amphetamine abuse; cocaine dependence; heroin dependence; and nicotine dependence. Orthologous to human GABBR1 (gamma-aminobutyric acid type B receptor subunit 1). PHENOTYPE: Phenotypes of null mice vary depending on strain background and allele. Homozygous null mice may display seizures, premature death, and abnormal nervous system electrophysiology. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
