| Primary Identifier | MGI:1202304 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 14711 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables glycine N-methyltransferase activity and glycine binding activity. Involved in S-adenosylmethionine metabolic process and protein homotetramerization. Acts upstream of or within several processes, including glycogen metabolic process; one-carbon metabolic process; and regulation of gluconeogenesis. Predicted to be part of methyltransferase complex. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; integumental system; limb; sensory organ; and skeleton. Used to study glycine N-methyltransferase deficiency and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in glycine N-methyltransferase deficiency. Orthologous to human GNMT (glycine N-methyltransferase). PHENOTYPE: Mice homozygous for a null mutation display elevated levels of methionine and S-adenosylmethionine in the liver. Mice homozygous for another null allele exhibit hepatitis, increased hepatic glycogen storage, and hepatocellular carcinoma. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
