| Primary Identifier | MGI:1861099 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 224826 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables histone H2A ubiquitin ligase activity. Involved in several processes, including meiotic nuclear division; negative regulation of gene expression, epigenetic; and ubiquitin-dependent protein catabolic process via the N-end rule pathway. Acts upstream of or within male meiosis I and ubiquitin-dependent protein catabolic process. Located in chromatin. Part of ubiquitin ligase complex. Is expressed in several structures, including alimentary system; endocrine gland; eye; genitourinary system; and trachea. Orthologous to human UBR2 (ubiquitin protein ligase E3 component n-recognin 2). PHENOTYPE: On a mixed genetic background, female homozygotes for a targeted null mutation exhibit embryonic lethality, while males are viable, but sterile due to postnatal testicular degeneration. On an inbred background, both genders die in utero. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
