Primary Identifier | MGI:1923239 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 224840 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable signaling receptor activity. Involved in positive regulation of defense response to virus by host; positive regulation of pattern recognition receptor signaling pathway; and protein localization. Acts upstream of or within T cell antigen processing and presentation and phagocytosis, engulfment. Located in endoplasmic reticulum. Colocalizes with endosome membrane and lysosomal membrane. Orthologous to human TREML4 (triggering receptor expressed on myeloid cells like 4). PHENOTYPE: Mice homozygous for a knock-out allele do not exhibit any significant alterations in the uptake and cross-presentation of dying cells. [provided by MGI curators] |