| Primary Identifier | MGI:1913150 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 83433 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including lipopolysaccharide binding activity; lipoteichoic acid binding activity; and peptidoglycan binding activity. Involved in several processes, including regulation of macromolecule metabolic process; regulation of signal transduction; and response to bacterium. Acts upstream of with a positive effect on social behavior. Acts upstream of or within with a positive effect on defense response to Gram-negative bacterium. Acts upstream of or within with a negative effect on pyroptotic inflammatory response. Acts upstream of or within negative regulation of NLRP3 inflammasome complex assembly; phagocytosis, engulfment; and regulation of gene expression. Located in plasma membrane. Is expressed in several structures, including body wall mesenchyme; central nervous system; genitourinary system; limb interdigital region; and skin. Used to study frontotemporal dementia. Human ortholog(s) of this gene implicated in Alzheimer's disease 17. Orthologous to human TREM2 (triggering receptor expressed on myeloid cells 2). PHENOTYPE: Mice homozygous for a knock-out allele display enhanced cytokine production by macrophages in response to toll-like receptor agonists. Mice homozygous for a different knock-out allele show reduced microglial cell survival, proliferation and activation and cell cycle arrest at the G1/S checkpoint. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
