| Primary Identifier | MGI:1335089 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 14154 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable EP4 subtype prostaglandin E2 receptor binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of inflammatory response. Acts upstream of or within negative regulation of MAP kinase activity and negative regulation of inflammatory response. Located in mitochondrion. Is expressed in several structures, including blastocyst; central nervous system; genitourinary system; retina; and spleen. Orthologous to human FEM1A (fem-1 homolog A). PHENOTYPE: Homozygous knockout results in an increased susceptibility to DSS-induced colitis and colitis-associated tumorigenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
