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Protein Coding Gene : Acer1 alkaline ceramidase 1
Primary Identifier  MGI:2181962 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  171168
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables N-acylsphingosine amidohydrolase activity. Involved in sebaceous gland development and sphingosine biosynthetic process. Acts upstream of or within ceramide catabolic process and regulation of lipid metabolic process. Located in endoplasmic reticulum. Orthologous to human ACER1 (alkaline ceramidase 1).
PHENOTYPE: Mice homozygous for a null allele show increased ceramide levels, hair shaft abnormalities, cyclic alopecia, epidermal hyperplasia, sebaceous gland and infundibulum expansion, increased epidermal water loss, and hypermetabolism along with decreased body weight and adipose tissue depots during aging. [provided by MGI curators]
  • synonyms:
  • MGI:1923689,
  • Acer1,
  • Asah3,
  • expressed sequence AI662009,
  • alkaline ceramidase 1,
  • AI662009,
  • N-acylsphingosine amidohydrolase (alkaline ceramidase) 3,
  • 2310024P18Rik,
  • MGI:2146910,
  • Cer1,
  • RIKEN cDNA 2310024P18 gene
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