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Protein Coding Gene : Alkbh7 alkB homolog 7
Primary Identifier  MGI:1913650 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  66400
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable metal ion binding activity. Involved in fatty acid metabolic process and regulation of lipid storage. Located in mitochondrial matrix. Is expressed in brown fat. Used to study obesity. Orthologous to human ALKBH7 (alkB homolog 7).
PHENOTYPE: Homozygous knockout affects lipid and carbohydrate metabolism which leads to obesity and increased sensitivity to diet-induced obesity. It also increases resistance to alkylation-induced cell death and mortality in males (and females for some tissues) and protects the heart from ischemia-reperfusion (IR) injury in males. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 2510008E23 gene,
  • spermatogenesis associated 11,
  • RIKEN cDNA 2310045B01 gene,
  • alkB homolog 7,
  • Abh7,
  • 2510008E23Rik,
  • MGI:1917538,
  • Spata11,
  • 2310045B01Rik,
  • Alkbh7
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