| Primary Identifier | MGI:99892 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 16772 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables glycosphingolipid binding activity and receptor ligand activity. An extracellular matrix structural constituent. Involved in positive regulation of Rac protein signal transduction; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of skeletal muscle acetylcholine-gated channel clustering. Acts upstream of or within several processes, including morphogenesis of an epithelium; neuron projection development; and retinal blood vessel morphogenesis. Located in basement membrane and cell-cell junction. Part of laminin-111 trimer. Is expressed in several structures, including alimentary system; extraembryonic component; eye; genitourinary system; and nervous system. Orthologous to human LAMA1 (laminin subunit alpha 1). PHENOTYPE: Homozygous null mice display embryonic lethality before somite formation with impaired formation of Reichert's membrane. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
