| Primary Identifier | MGI:1918141 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 70891 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein kinase activator activity and protein kinase binding activity. Involved in male meiotic nuclear division and positive regulation of cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within several processes, including chromosome organization; establishment of protein localization to telomere; and spermatogenesis. Located in XY body; chromosome, telomeric region; and nuclear envelope. Is expressed in reproductive system. Orthologous to human SPDYA (speedy/RINGO cell cycle regulator family member A). PHENOTYPE: Homozygous inactivation of this gene results in impaired telomere attachment to the nuclear envelope during early meiosis, abnormal chromosome pairing and homologous synapsis, and meiotic prophase I arrest in male and female germ cells leading to infertility in both sexes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
