Primary Identifier | MGI:2684937 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 225010 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables acyltransferase activity. Predicted to be involved in phosphatidylinositol acyl-chain remodeling. Located in endoplasmic reticulum. Is expressed in several structures, including gut; heart; immune system; ovary; and respiratory system. Orthologous to human LCLAT1 (lysocardiolipin acyltransferase 1). PHENOTYPE: Male mice homozygous for a knock-out allele and fed a high fat diet exhibit resistance to diet induced obesity, decreased total body fat, increased insulin sensitivity, polyphagia, hyperactivity, increased energy expenditure, and increased fatty acid oxidation. [provided by MGI curators] |