Primary Identifier | MGI:1915277 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 68027 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in negative regulation of osteoclast differentiation and regulation of cytosolic calcium ion concentration. Located in endoplasmic reticulum membrane. Is expressed in brain and ventral grey horn. Orthologous to human TMEM178A (transmembrane protein 178A). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased bone mass, osteopenia, and increased osteoclast differentiation under basal and inflammatory conditions. [provided by MGI curators] |