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Protein Coding Gene : Dync2li1 dynein cytoplasmic 2 light intermediate chain 1
Primary Identifier  MGI:1913996 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  213575
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable dynein heavy chain binding activity. Acts upstream of or within cilium assembly and determination of left/right symmetry. Located in apical part of cell; axoneme; and motile cilium. Is expressed in several structures, including gut; heart; lung; metanephros; and node. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human DYNC2LI1 (dynein cytoplasmic 2 light intermediate chain 1).
PHENOTYPE: Mice homozygous for disruptions in this allele die before embryonic day 11.5. They display neural tube defects in addition to a variety developmental patterning abnormalities. [provided by MGI curators]
  • synonyms:
  • LIC3,
  • mD2LIC,
  • dynein cytoplasmic 2 light intermediate chain 1,
  • RIKEN cDNA 4933404O11 gene,
  • dynein 2 light intermediate chain,
  • Dync2li1,
  • MGC:7211,
  • CGI-60,
  • D2lic,
  • 4933404O11Rik,
  • MGC:40646
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