| Primary Identifier | MGI:1914690 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 67440 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including metal ion binding activity; poly(A) RNA polymerase activity; and ribonucleotide binding activity. Predicted to be involved in histone mRNA catabolic process and mitochondrial RNA 3'-end processing. Located in mitochondrion. Is expressed in several structures, including early conceptus; liver lobe; and oocyte. Human ortholog(s) of this gene implicated in spastic ataxia 4. Orthologous to human MTPAP (mitochondrial poly(A) polymerase). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete embryonic lethality by E9.5. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
