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Protein Coding Gene : Dsc1 desmocollin 1
Primary Identifier  MGI:109173 Organism  mouse, laboratory
Chromosome  18 NCBI Gene Number  13505
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable calcium ion binding activity. Involved in desmosome maintenance; negative regulation of epithelial cell proliferation; and skin epidermis development. Located in desmosome. Is expressed in epithelium and skin. Orthologous to human DSC1 (desmocollin 1).
PHENOTYPE: Mutants with targeted disruptions of this gene have fragile epidermis, flaky skin, and defects in the epidermal barrier, leading to chronic dermatitis and display abnormal epidermal differentiation as indicated by hyperproliferation and overxpression of keratin 6 and 16. [provided by MGI curators]
  • synonyms:
  • expressed sequence AI507491,
  • MGI:2147239,
  • desmocollin 1,
  • Dsc1a,
  • RIKEN cDNA 1110020A10 gene,
  • Dsc1,
  • Dsc1b,
  • 1110020A10Rik,
  • MGD-MRK-38217,
  • AI507491,
  • MGI:1915898
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Features --> Cross References

Genome

Sequence Feature Displayer

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

6 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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