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Protein Coding Gene : Mzb1 marginal zone B and B1 cell-specific protein 1
Primary Identifier  MGI:1917066 Organism  mouse, laboratory
Chromosome  18 NCBI Gene Number  69816
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Involved in several processes, including integrin activation; positive regulation of immunoglobulin production; and regulation of B cell proliferation. Located in endoplasmic reticulum lumen and extracellular region. Part of endoplasmic reticulum chaperone complex. Is expressed in thymus primordium. Orthologous to human MZB1 (marginal zone B and B1 cell specific protein).
PHENOTYPE: Constitutive and B cell specific conditional homozygous KO impairs the immune response by affecting B cell maturation. [provided by MGI curators]
  • synonyms:
  • pERp1,
  • Mzb1,
  • MGI:2147333,
  • marginal zone B and B1 cell-specific protein 1,
  • RIKEN cDNA 2010001M09 gene,
  • expressed sequence AV064572,
  • 2010001M09Rik,
  • AV064572
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